hrp0086p1-p751 | Pituitary and Neuroendocrinology P1 | ESPE2016

Transcriptional Basis of Idiopathic Central Hypogonadism in Isolated Congenital Cryptorchidism with Defective Mini-Puberty

Hadziselimovic Faruk , Gegenschatz Katharina , Verkauskas Gilvydas , Demougin Philippe , Stadler Michael , Bilius Vytautas , Malcius Dalius , Dasevicius Darius

Objective and hypotheses: The objective was to use whole-genome RNA profiling of testicular biopsies by DNA strand-specific RNA-sequencing to explore the causative role of isolated congenital cryptorchidism in azoospermia and/or infertility.Method: Fifteen cryptorchid patients, aged 7 months to 5 years, were enrolled in this study and underwent orchidopexy. During surgery, testicular tissue biopsies were collected and split in half for histological exami...